Fri Feb 04 2022

38 articles - From Saturday Jan 29 2022 to Friday Feb 04 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Rheumatology (Oxford)

A systematic review and meta-analysis of Mycobacterial infections in patients with idiopathic inflammatory myopathies.

TB is common in IIM, particularly in endemic regions though current data is largely heterogeneous. Extra-pulmonary forms &atypical sites including the muscle are frequent. Limited data suggests fair outcomes, although larger prospective studies may offer better understanding.

Pubmed   Journal   ReadQx 

Pharmacological treatment in adult patients with CRPS-I: A systematic review and meta-analysis of randomised controlled trials.

This systematic review and meta-analysis supports the recommendation of parenteral bisphosphonates as the first-line agent in the treatment of CRPS-I. Registration number Open Science Framework registries; osf.io/et9gu.

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Studies

RCT, clinical trials, retrospective studies, etc…

Ann Rheum Dis

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis.

The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis demonstrate strong performance characteristics and are validated for use in research.

Pubmed   Journal   ReadQx 

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for granulomatosis with polyangiitis.

The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for GPA demonstrate strong performance characteristics and are validated for use in research.

Pubmed   Journal   ReadQx 

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for microscopic polyangiitis.

The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for MPA are now validated for use in clinical research.

Pubmed   Journal   ReadQx 

EULAR recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, including systemic lupus erythematosus and antiphospholipid syndrome.

These recommendations can guide clinical practice and future research for improving CVR management in rheumatic and musculoskeletal diseases.

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Psoriasis rate is increased by the exposure to TNF inhibition in children with JIA.

In a large prospective JIA patient registry, we observed a nearly threefold increased risk of psoriasis after TNFi exposureCite Now.

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The 2021 EULAR and ACR points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS.

These points to consider represent state-of-the-art knowledge to guide diagnostic evaluation, treatment and management of patients with CANDLE/PRAAS, SAVI and AGS and aim to standardise and improve care, quality of life and disease outcomes.

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Arthritis Care Res (Hoboken)

Differences in the association between oral corticosteroids and risk of preterm birth by data source: Reconciling the results.

Higher baseline PTB risk and lower OCS dose distribution in Medi-Cal may explain the discrepancies. Studies are needed to understand the effects of autoimmune disease severity and under-treatment on PTB risk in low-income populations.

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Arthritis Res Ther

Associations between the morphological parameters of proximal tibiofibular joint (PTFJ) and changes in tibiofemoral joint structures in patients with knee osteoarthritis.

This longitudinal study suggests that higher load-bearing area of PTFJ could be a risk factor for structural changes in medial tibiofemoral (MTF) compartment in knee OA.

Pubmed   Journal   ReadQx   PMC

Arthritis Rheumatol

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis With Polyangiitis.

The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for EGPA demonstrate strong performance characteristics and are validated for use in research.

Pubmed   Journal   ReadQx 

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Granulomatosis With Polyangiitis.

The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for GPA demonstrate strong performance characteristics and are validated for use in research.

Pubmed   Journal   ReadQx 

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis.

The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for MPA are now validated for use in clinical research.

Pubmed   Journal   ReadQx 

Aptamer-based screen of Neuropsychiatric Lupus cerebrospinal fluid reveals potential biomarkers that overlap with the choroid plexus transcriptome.

CSF Lipocalin-2, M-CSF, IgM and complement C3 emerge as promising CSF biomarkers of NPSLE with diagnostic potential.

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Rheumatology (Oxford)

An unusual cause of a halo sign.

An 86-year-old man was referred with an 8-week history of unilateral frontotemporal headache and claudicant jaw pain. Recent antibiotics for a suspected right-sided acute otitis interna and externa had not improved his symptoms. Systemic review revealed weight loss, fatigue and anorexia, but no fever.

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Carbamylation of ß2-GPI generates new autoantigens for Antiphospholipid Syndrome: a new tool for diagnosis of "seronegative" patients.

Data obtained from both functional tests on moDCs and from immunologic approaches prompted identification of Carb-ß2-GPI as a "new" antigenic target in APS. In particular, anti-Carb-ß2-GPI revealed a potential usefulness in identification of a significant proportion of SN-APS patients. Moreover, since patients tested positive for anti-Carb-ß2-GPI reported a high risk of thrombocytopenia, this test may be considered a suitable approach in the clinical evaluation of SN-APS.

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Conversion of the MDHAQ to the HAQ score-a simple algorithm developed and validated in a cohort of 13,391 real-world patients.

This study suggests that in observational datasets with only the MDHAQ available a simple algorithm allows valid conversion to HAQ on the group level in RA, PsA and axSpA.

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Deep learning algorithms for magnetic resonance imaging of inflammatory sacroiliitis in axial spondyloarthritis.

An MRI deep learning algorithm was developed for detection of inflammatory sacroiliitis in axial SpA.

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Domains and outcome measures for the assessment of limited cutaneous systemic sclerosis: an international collaborative scoping review.

This scoping literature review provides a comprehensive identification of domains and outcomes used to assess lcSSc. Our results also highlight that lcSSc is under-represented in the literature.

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Humoral immunogenicity of COVID-19 vaccines in patients with inflammatory rheumatic diseases under treatment with Rituximab: a case-control study (COVID-19VacRTX).

The study confirms the negative impact of RTX on antibody level after vaccination against SARS-CoV-2. A clear relationship exists between antibody titre and interval of the last infusion to the first vaccination, number of peripheral B-cells and immunoglobulin quantity. These parameters help improve synchronization of vaccination and RTX therapy regimen.

Pubmed   Journal   ReadQx   PMC

Lymphocyte subset abnormalities in early severe scleroderma favor a Th2 phenotype and are not altered by prior immunosuppressive therapy.

In patients with early, severe SSc, significant lymphocyte subset abnormalities were observed. Prior treatment with immunosuppressive therapy did not impact the immunophenotype, suggesting that lymphocyte disturbances in scleroderma appeared due to the disease itself.

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Machine Learning using Genetic and Clinical Data Identifies a Signature that Robustly Predicts Methotrexate Response in Rheumatoid Arthritis.

Sensitive and specific predictors of MTX response in RA patients were identified in this study through a novel strategy combining biologically meaningful and machine learning feature selection and training. These predictors may facilitate better treatment decision-making in RA management.

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Management of severe renal disease in anti-neutrophil-cytoplasmic-antibody-associated vasculitis: place of rituximab and plasma exchange?

We could not find any difference between RTX and CYC as induction therapy for patients with severe AAV-related glomerulonephritis. In patients receiving CYC induction regimen, the addition of PE conferred short-term benefits with higher dialysis-free rate at M12.

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Morphological characteristics of DISH in patients with OPLL and its association with high-sensitivity CRP: Inflammatory DISH.

The Flat type in DISH might be caused by an inflammatory pathogenesis rather than a degenerative process presented in the Jaggy type.

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Patterns of biologic and targeted-synthetic disease-modifying antirheumatic drug use in rheumatoid arthritis in Australia.

Switching between b/tsDMARDs was common among ARAD participants with RA, most commonly due to inefficacy or adverse effects. Durability of exposure and reasons for switching varied between b/tsDMARDs.

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Prevalence of moderate to severe lower urinary tract symptoms in systemic sclerosis.

Moderate to severe LUTS occurred in about one-fifth of SSc patients, particularly those with extensive skin tightness and gastrointestinal involvement. The more severe the LUTS, the poorer the quality of life.

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The prognostic value of sST2 in connective tissue disease patients with pulmonary hypertension.

sST2=39.99ng/ml predicts higher incidence of clinical worsening event in CTD-PH patients. Furthermore, patients with elevated sST2 had significantly worse prognosis among those with high NT-proBNP.

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Ultrasound findings of calcium pyrophosphate deposition disease at metacarpophalangeal joints.

This study provides pictorial evidence of the broad spectrum of US findings indicating CPP deposits at MCP joints in CPPD. Furthermore, we reported different US patterns in different CPPD phenotypes.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Arthritis Res Ther

Role of the S100 protein family in rheumatoid arthritis.

The overexpression of most S100 proteins in rheumatoid arthritis is closely related to its pathogenesis. This paper reviews the relationship between S100 proteins and the occurrence and development of rheumatoid arthritis. It will provide insights into the development of new clinical diagnostic markers and therapeutic targets for rheumatoid arthritis.

Pubmed   Journal   ReadQx   PMC

Arthritis Rheumatol

New Classification Criteria for Small-Vessel Vasculitis: Is Antineutrophil Cytoplasmic Antibody Inclusion Their Major Advance?

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Letters&Replies

Letters to the editors and authors’ replies


Others

all remaining publications eg case reports, images of the month, etc…

Ann Rheum Dis

Effectiveness and safety of combined biological therapy in patients with refractory multidomain spondyloarthritis.

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Has the gout epidemic peaked in the UK? A nationwide cohort study using data from the Clinical Practice Research Datalink, from 1997 to across the COVID-19 pandemic in 2021.

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Management of contemporary early undifferentiated arthritis: data on EULAR's recommendation on the risk of persistent disease.

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Serum interferon-a levels and IFN type I-stimulated genes score perform equally to assess systemic lupus erythematosus disease activity.

Pubmed   Journal   ReadQx 

Rheumatology (Oxford)

Improvements of vascular outcomes in systemic sclerosis: halfway through, but still far to go.

Pubmed   Journal   ReadQx 

Let's talk about shoulder osteoarthritis.

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Rheumatologists have an important role in the management of interstitial lung disease (ILD): a cross-speciality, multi-centre, U.K. perspective.

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VEXAS syndrome: Favourable clinical and partial haematological responses to subcutaneous abatacept therapy with 30-month follow up.

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